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Engineering genomes in multiplex

Paper ID Volume ID Publish Year Pages File Format Full-Text
15734 42471 2011 8 PDF Available
Title
Engineering genomes in multiplex
Abstract

Efficiently engineering robust complex traits is a key challenge facing metabolic engineering efforts to synthesize valuable products in vivo. Recent advances in genome engineering confront this barrier and significantly enhance the ability to map functional changes targeted throughout the genome and combinatorially optimize complex (multigenic) traits using multiplex recombineering. We describe a framework for efficiently searching genome-wide combinatorial space to optimize complex traits and highlight recent advances in genome engineering that enable this approach.

► An algorithm for genome engineering of complex traits is presented. ► To efficiently search for trait-conferring mutations, targeted, functional mutations should be used to introduce genetic diversity. ► Combinatorial optimization on the genome-scale requires narrowing to relevant genetic targets to efficiently search the genotypic space. ► We review advances in multiplex recombineering and their application to genome engineering.

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Publisher
Database: Elsevier - ScienceDirect
Journal: Current Opinion in Biotechnology - Volume 22, Issue 4, August 2011, Pages 576–583
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us