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Adaptive laboratory evolution — harnessing the power of biology for metabolic engineering

Paper ID Volume ID Publish Year Pages File Format Full-Text
15736 42471 2011 5 PDF Available
Title
Adaptive laboratory evolution — harnessing the power of biology for metabolic engineering
Abstract

Adaptive laboratory evolution (ALE) strategies allow for the metabolic engineering of microorganisms by combining genetic variation with the selection of beneficial mutations in an unbiased fashion. These ALE strategies have been proven highly effective in the optimization of production strains. In contrast to rational engineering strategies and directed modification of specific enzymes, ALE has the advantage of letting nonintuitive beneficial mutations occur in many different genes and regulatory regions in parallel. So far, the majority of applications of ALE in metabolic engineering have used well-characterized platform organisms such as Saccharomyces cerevisiae and Escherichia coli; however, applications for other microorganisms are on the rise. This review will focus on current applications of ALE as a tool for metabolic engineering and discuss advancements and achievements that have been made in this field.

► Adaptive laboratory evolution (ALE) as a tool for metabolic engineering. ► Latent pathway activation by ALE. ► ALE has successfully been used to optimize the phenotype of a microorganism. ► Adaptation to changing environments by ALE.

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Adaptive laboratory evolution — harnessing the power of biology for metabolic engineering
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Publisher
Database: Elsevier - ScienceDirect
Journal: Current Opinion in Biotechnology - Volume 22, Issue 4, August 2011, Pages 590–594
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us