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The role of cellular objectives and selective pressures in metabolic pathway evolution

Paper ID Volume ID Publish Year Pages File Format Full-Text
15737 42471 2011 6 PDF Available
Title
The role of cellular objectives and selective pressures in metabolic pathway evolution
Abstract

Evolution results from molecular-level changes in an organism, thereby producing novel phenotypes and, eventually novel species. However, changes in a single gene can lead to significant changes in biomolecular networks through the gain and loss of many molecular interactions. Thus, significant insights into microbial evolution have been gained through the analysis and comparison of reconstructed metabolic networks. However, challenges remain from reconstruction incompleteness and the inability to experiment with evolution on the timescale necessary for new species to arise. Despite these challenges, experimental laboratory evolution of microbes has provided some insights into the cellular objectives underlying evolution, under the constraints of nutrient availability and the use of mechanisms that protect cells from extreme conditions.

► Evolution involves a rewiring of molecular interactions and networks over time. ► Selective pressures interact with cellular objectives to evolve metabolic networks. ► Metabolic pathways adapt to optimize metabolism subject to nutrient availability. ► Metabolic pathways adapt to protect the microbe against environmental stresses. ► Adaptive laboratory evolution has provided insight into how pathways evolve.

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The role of cellular objectives and selective pressures in metabolic pathway evolution
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Publisher
Database: Elsevier - ScienceDirect
Journal: Current Opinion in Biotechnology - Volume 22, Issue 4, August 2011, Pages 595–600
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
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