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Recombinant live vaccine candidates against tuberculosis

Paper ID Volume ID Publish Year Pages File Format Full-Text
15853 42474 2012 8 PDF Available
Title
Recombinant live vaccine candidates against tuberculosis
Abstract

Tuberculosis (TB) remains among the most deadly health threats to humankind despite availability of several potent antibiotics and a vaccine, bacille Calmette-Guérin (BCG). BCG partially protects children but not adults from the disease. Growing knowledge of the molecular basis of infection, immunity, and pathology in TB has driven various approaches, which strive to complement or replace BCG with more effective vaccines. Three recombinant live TB vaccine candidates have entered clinical trials. These candidates have been genetically engineered to be attenuated, to overexpress TB antigens and/or to secrete bacterial perforins, ultimately seeking to trigger a robust immune response thereby providing long-lasting protection against TB.

Graphical abstractFigure optionsDownload full-size imageDownload high-quality image (265 K)Download as PowerPoint slideHighlights► A robust pipeline of recombinant live TB vaccines aims to replace BCG. ► Current candidates are better than BCG in controlling TB in preclinical models. ► Three candidates in clinical trials signal hope for medium-term market introduction. ► Candidates do not prevent or eradicate infection. ► BCG can serve as vaccine platform to address the needs of diseases other than TB.

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Recombinant live vaccine candidates against tuberculosis
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Publisher
Database: Elsevier - ScienceDirect
Journal: Current Opinion in Biotechnology - Volume 23, Issue 6, December 2012, Pages 900–907
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us