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Genetic engineering of attenuated malaria parasites for vaccination

Paper ID Volume ID Publish Year Pages File Format Full-Text
15854 42474 2012 9 PDF Available
Title
Genetic engineering of attenuated malaria parasites for vaccination
Abstract

Vaccination with live-attenuated Plasmodium sporozoites that arrest in the liver can completely protect against a malaria infection both in animal models and in humans; this has provided the conceptual basis for the most promising, but also challenging, approach to develop an efficacious malaria vaccine. Advances in genetic manipulation of Plasmodium in conjunction with improved genomic and biological information has enabled new approaches to design genetically attenuated parasites (GAPs). In this review we discuss the principles in discovery and development of GAPs in preclinical models that are important in selecting GAP parasites for first-in-human clinical studies. Finally, we highlight the challenges in manufacture, formulation and delivery of a live-attenuated whole parasite malaria vaccine, as well as the further refinements that may be implemented in the next generation GAP vaccines.

Graphical abstractFigure optionsDownload full-size imageDownload high-quality image (242 K)Download as PowerPoint slideHighlights► Genetically attenuated parasites (GAPs) as potential vaccines against malaria. ► Attenuated Plasmodium sporozoites confer sustained sterile immunity against malaria. ► Rodent malaria models are an important in vivo platform to delineate GAP safety and potency. ► Late liver-arresting GAPs elicit superior protective immunity than early arresting parasites. ► P. falciparum GAP vaccine candidates need ultimately to be validated in clinical studies.

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Genetic engineering of attenuated malaria parasites for vaccination
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Publisher
Database: Elsevier - ScienceDirect
Journal: Current Opinion in Biotechnology - Volume 23, Issue 6, December 2012, Pages 908–916
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us