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Engineering commensal bacteria for prophylaxis against infection

Paper ID Volume ID Publish Year Pages File Format Full-Text
15856 42474 2012 7 PDF Available
Title
Engineering commensal bacteria for prophylaxis against infection
Abstract

Infectious diseases are the leading causes of death worldwide. The development of efficient and low cost prophylactics to prevent pathogenic infection is given high priority in the twenty-first century. Commensal bacteria are largely seen as harmless and can survive symbiotically (in many cases) in niches throughout the human body. Advances in genetic engineering and understanding of pathogenesis have revealed many potential strategies to develop engineered bacteria for prophylaxis purposes: including live vaccines and anti-infective agents. In this review, we discuss recent advances and potentialities of prophylaxis with engineered bacteria.

Graphical abstractFigure optionsDownload full-size imageDownload high-quality image (147 K)Download as PowerPoint slideHighlight► Advantages of using commensal bacteria as delivery systems. ► Different strategies were used to engineer commensal bacteria to target bacterial or viral infection through inhibiting virulence expression, producing bacteriocins, neutralizing toxins, preventing adhesion, blocking fusion sites, and enhancing the immune response of host cells. ► Current challenges and future perspectives were also discussed.

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Engineering commensal bacteria for prophylaxis against infection
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Publisher
Database: Elsevier - ScienceDirect
Journal: Current Opinion in Biotechnology - Volume 23, Issue 6, December 2012, Pages 924–930
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us