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Genome-based bioprospecting of microbes for new therapeutics

Paper ID Volume ID Publish Year Pages File Format Full-Text
15858 42474 2012 7 PDF Available
Title
Genome-based bioprospecting of microbes for new therapeutics
Abstract

Bioprospecting of natural sources for new medicines has a long and successful history, exemplified by the fact that over 50% of all drugs currently on the market are either derived from or inspired by natural products. However, development of new natural product-based therapeutics has been on the decline over the past 20 years, mainly owing to frequent re-discovery of already known compounds coupled with high costs for screening, characterization and development. With the onset of the genomic era allowing rapid sequencing and analysis of bacterial and fungal genomes, it became evident that these organisms possess ‘hidden treasures’ in the form of gene clusters potentially governing biosynthesis of novel biologically active compounds. This review highlights current progress in mining for and expression of these gene clusters, which may revolutionize the drug discovery pipelines in the near future.

Graphical abstract.Figure optionsDownload full-size imageDownload high-quality image (124 K)Download as PowerPoint slideHighlights► Microbial genomes contain multiple clusters for biosynthesis of chemically diverse compounds. ► Most of such genes remain silent, preventing the respective compounds from being discovered. ► Silent gene clusters can be activated and/or heterologously expressed. ► New microbial hosts and tools are needed to make the abovementioned process efficient. ► Synthetic biology will play a major role in the genome-based drug discovery.

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Publisher
Database: Elsevier - ScienceDirect
Journal: Current Opinion in Biotechnology - Volume 23, Issue 6, December 2012, Pages 941–947
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us