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A retrosynthetic biology approach to therapeutics: from conception to delivery

Paper ID Volume ID Publish Year Pages File Format Full-Text
15859 42474 2012 9 PDF Available
Title
A retrosynthetic biology approach to therapeutics: from conception to delivery
Abstract

De novo biosynthetic pathways are designed, assembled and optimized to produce high-value compounds such as drugs and chemical building blocks from renewable resources. Microorganisms are used as synthetic platforms of systems biology where biochemical pathways are engineered into the host metabolic network. Retrosynthetic biology offers a creative pathway design concept that has gained interest because of its potential to identify novel metabolic ways for therapeutic production. Retrosynthetic biology uses the backward search of retrosynthetic analysis to devise and optimize tailor-made pathways. The retrosynthetic process can be seamlessly integrated into a complete circuitry system for therapeutic applications where production, sensing and delivery act as constitutive interconnecting parts. The aim of this review is to highlight recent efforts toward synthetic design for therapeutic development.

Graphical abstractFigure optionsDownload full-size imageDownload high-quality image (115 K)Download as PowerPoint slideHighlights► Retrosynthetic biology has the potential to identify de novo circuits for therapeutics. ► Retrosynthetic biology performs a metabolic backward search to devise and optimize pathways. ► Production, sensing, and delivery circuits are essential parts of next-generation therapeutics.

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A retrosynthetic biology approach to therapeutics: from conception to delivery
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Publisher
Database: Elsevier - ScienceDirect
Journal: Current Opinion in Biotechnology - Volume 23, Issue 6, December 2012, Pages 948–956
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us