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Pharmaceutical protein production by yeast: towards production of human blood proteins by microbial fermentation

Paper ID Volume ID Publish Year Pages File Format Full-Text
15861 42474 2012 7 PDF Available
Title
Pharmaceutical protein production by yeast: towards production of human blood proteins by microbial fermentation
Abstract

Since the approval of recombinant insulin from Escherichia coli for its clinical use in the early 1980s, the amount of recombinant pharmaceutical proteins obtained by microbial fermentations has significantly increased. The recent advances in genomics together with high throughput analysis techniques (the so-called — omics approaches) and integrative approaches (systems biology) allow the development of novel microbial cell factories as valuable platforms for large scale production of therapeutic proteins. This review summarizes the main achievements and the current situation in the field of recombinant therapeutics using yeast Saccharomyces cerevisiae as a model platform, and discusses the future potential of this platform for production of blood proteins and substitutes.

Graphical abstractFigure optionsDownload full-size imageDownload high-quality image (258 K)Download as PowerPoint slideHighlights► Recombinant therapeutic protein production is a multibillion dollar market. ► E. coli comprises 30% of recombinant protein production but not suitable for human therapeutics. ► Eukaryotic systems other than yeast are costly or not so efficient regarding protein yields. ► S. cerevisiae shows a high potential to be a suitable platform for therapeutic proteins. ► Human blood proteins are the next candidates to be challenged by S. cerevisiae system.

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Publisher
Database: Elsevier - ScienceDirect
Journal: Current Opinion in Biotechnology - Volume 23, Issue 6, December 2012, Pages 965–971
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us