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Vault particles: a new generation of delivery nanodevices

Paper ID Volume ID Publish Year Pages File Format Full-Text
15862 42474 2012 6 PDF Available
Title
Vault particles: a new generation of delivery nanodevices
Abstract

Vault particles possess many attributes that can be exploited in nanobiotechnology, particularly in the creation of drug delivery nanodevices. These include self-assembly, 100 nm size range, a dynamic structure that may be controlled for manipulation of drug release kinetics and natural presence in humans ensuring biocompatibility. The flexibility and the adaptability of this system have been greatly enhanced by the emerging atomic-level information and improved comprehension of vault structure and dynamics. It seems likely that this information will allow their specific tailoring to the individual requirements of each drug and target tissue. These properties provide vaults with an enormous potential as a versatile delivery platform.

Graphical abstractFigure optionsDownload full-size imageDownload high-quality image (270 K)Download as PowerPoint slideHighlights► Vault particles can be exploited in nanobiotechnology as drug delivery nanodevices. ► The structural information of vaults would serve as a guide for rational engineering. ► The dynamic structure of vaults may be controlled for manipulation of drug release. ► Engineered vaults allow specific cell targeting and controlled encapsulation.

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Publisher
Database: Elsevier - ScienceDirect
Journal: Current Opinion in Biotechnology - Volume 23, Issue 6, December 2012, Pages 972–977
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
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