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Pathways of unconventional protein secretion

Paper ID Volume ID Publish Year Pages File Format Full-Text
15901 42476 2010 6 PDF Available
Title
Pathways of unconventional protein secretion
Abstract

The vast majority of extracellular proteins are secreted by the classical endoplasmic reticulum (ER)/Golgi-dependent pathway, however, numerous exceptions have been identified. Unconventional secretory proteins lack signal peptides and their export from cells is not affected by brefeldin A, an inhibitor of protein transport along the classical secretory pathway. Two general types of unconventional secretion exist. First, export mediated by direct translocation across plasma membranes of cytoplasmic proteins such as fibroblast growth factor 2. Second, export involving intracellular transport intermediates as shown for acyl-CoA binding protein. Here, molecular mechanisms and factors involved in unconventional secretion are discussed with a focus on fibroblast growth factor 2 translocation across plasma membranes and the role of autophagosomes in unconventional secretion of acyl-CoA binding protein.

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Pathways of unconventional protein secretion
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Publisher
Database: Elsevier - ScienceDirect
Journal: Current Opinion in Biotechnology - Volume 21, Issue 5, October 2010, Pages 621–626
Authors
,
Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us