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Molecular-level tradeoffs and metabolic adaptation to simultaneous stressors

Paper ID Volume ID Publish Year Pages File Format Full-Text
15909 42476 2010 7 PDF Available
Title
Molecular-level tradeoffs and metabolic adaptation to simultaneous stressors
Abstract

Life is a dynamic process driven by the complex interplay between physical constraints and selection pressures, ranging from nutrient limitation to inhibitory substances to predators. These stressors are not mutually exclusive; microbes have faced concurrent challenges for eons. Genome-enabled systems biology approaches are adapting economic and ecological concepts like tradeoff curves and strategic resource allocation theory to analyze metabolic adaptations to simultaneous stressors. These methodologies can accurately describe and predict metabolic adaptations to concurrent stresses by considering the tradeoff between investment of limiting resources into enzymatic machinery and the resulting cellular function. The approaches represent promising links between computational biology and well-established economic and ecological methodologies for analyzing the interplay between physical constraints and microbial fitness.

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Molecular-level tradeoffs and metabolic adaptation to simultaneous stressors
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Publisher
Database: Elsevier - ScienceDirect
Journal: Current Opinion in Biotechnology - Volume 21, Issue 5, October 2010, Pages 670–676
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us