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Improved attachment of mesenchymal stem cells on super-hydrophobic TiO2 nanotubes

Paper ID Volume ID Publish Year Pages File Format Full-Text
1592 86 2008 7 PDF Available
Title
Improved attachment of mesenchymal stem cells on super-hydrophobic TiO2 nanotubes
Abstract

Self-organized layers of vertically orientated TiO2 nanotubes providing defined diameters ranging from 15 up to 100 nm were grown on titanium by anodic oxidation. These TiO2 nanotube layers show super-hydrophilic behavior. After coating TiO2 nanotube layers with a self-assembled monolayer (octadecylphosphonic acid) they showed a diameter-dependent wetting behavior ranging from hydrophobic (108 ± 2°) up to super-hydrophobic (167 ± 2°). Cell adhesion, spreading and growth of mesenchymal stem cells on the unmodified and modified nanotube layers were investigated and compared. We show that cell adhesion and proliferation are strongly affected in the super-hydrophobic range. Adsorption of extracellular matrix proteins as fibronectin, type I collagen and laminin, as well as bovine serum albumin, on the coated and uncoated surfaces showed a strong influence on wetting behavior and dependence on tube diameter.

Keywords
Titanium-dioxide nanotubes; Self assembled monolayers; Super-hydrophobic; Cell adhesion; Mesenchymal stem cells
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Improved attachment of mesenchymal stem cells on super-hydrophobic TiO2 nanotubes
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Publisher
Database: Elsevier - ScienceDirect
Journal: Acta Biomaterialia - Volume 4, Issue 5, September 2008, Pages 1576–1582
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us