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Gut metabotypes govern health effects of dietary polyphenols

Paper ID Volume ID Publish Year Pages File Format Full-Text
15932 42478 2013 6 PDF Available
Title
Gut metabotypes govern health effects of dietary polyphenols
Abstract

Polyphenols are thought to be responsible for some of the health effects conferred by a diet rich in fruit and vegetables. Both the formation of bioactive polyphenol-derived metabolites and the modulation of colonic microbiota contribute to these health benefits. Therefore, one cannot infer biological responses from dietary intake records without considering polyphenol–microbiota interactions. However, the latter are complex and subject to large interindividual variability, leading to different polyphenol-metabolizing phenotypes or ‘metabotypes’. Based on accurate measurements of intake, exposure and effect on carefully selected samples, the physiological relevance of dietary polyphenols can be evaluated for each metabotype. Ultimately, this will lead to predictive modeling and the development of (personalized) functional foods and other nutraceuticals with maximized health benefits.

Graphical abstractFigure optionsDownload full-size imageDownload high-quality image (292 K)Download as PowerPoint slideHighlights► Health effects of dietary polyphenols often depend on multiple metabolic processes. ► Gut metabotypes with specific polyphenol metabolism patterns can be differentiated. ► Physiologically achievable concentrations of relevant metabolites should be tested. ► Novel products and applications can exploit polyphenol–microbiota interactions.

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Publisher
Database: Elsevier - ScienceDirect
Journal: Current Opinion in Biotechnology - Volume 24, Issue 2, April 2013, Pages 220–225
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
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Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
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