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Mechanistic pathway modeling for industrial biotechnology: challenging but worthwhile

Paper ID Volume ID Publish Year Pages File Format Full-Text
15954 42479 2011 7 PDF Available
Title
Mechanistic pathway modeling for industrial biotechnology: challenging but worthwhile
Abstract

Mechanistic (also called kinetic) models quantitatively describe dynamic and steady states of biochemical pathways. They are based on network structure (stoichiometry), regulatory information (enzyme inhibitors and activators) and the corresponding reaction kinetics. Although this approach to understand and predict the behavior of biochemical networks has now been in use for almost half a century, its experimental foundation has dramatically changed in the data-rich age of systems biology. Large mechanistic models, ranging up to the genome scale, are now being built and lots of data are available to validate and test them. From the broad scope of possible modeling applications, this survey focuses on the recent developments and central problems of metabolic network modeling in the field of bioprocess development for industrial biotechnology.

Research highlights► Models of pathway regulation are highly valuable for bioprocess development. ► Both horizontal networks (metabolites, genes) and their vertical coupling must be considered. ► Model detail must be properly adjusted to the goals of investigation. ► Mechanistic models are data hungry but not all parameters are important. ► Modeling efforts are a major driving force for quantitative bioanalytics.

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Publisher
Database: Elsevier - ScienceDirect
Journal: Current Opinion in Biotechnology - Volume 22, Issue 5, October 2011, Pages 604–610
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us