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Pathway engineering for functional isoprenoids

Paper ID Volume ID Publish Year Pages File Format Full-Text
15957 42479 2011 7 PDF Available
Title
Pathway engineering for functional isoprenoids
Abstract

Pathway engineering is to engineer biosynthetic pathways for compounds of interests in heterologous organisms such as microbes and higher plants, which has also been one of the most important fields in metabolic engineering and synthetic biology. This review focuses on pathway engineering researches for the production of functional isoprenoids containing monoterpenes, sesquiterpenes, diterpenes, and triterpenes as well as carotenoids and for the elucidation of relevant biosynthesis genes and enzymes, which have been performed in the last two years. As microbial hosts, Escherichia coli and Saccharomyces cerevisiae have often been employed, since they, specifically the former, are fully amenable to genetic manipulations with extensive molecular resources. Various crops have also been used as the hosts for engineering pathways of functional isoprenoids of the plant origin, particularly carotenoids.

Graphical abstractFigure optionsDownload full-size imageDownload high-quality image (150 K)Download as PowerPoint slideResearch highlights► Pathway engineering is to engineer biosynthetic pathways for compounds of interests in heterologous organisms. ► Pathway engineering for the efficient production of functional isoprenoids has been performed with microbial hosts. ► Understanding biosynthetic pathways of the isoprenoids are important for their heterologous production. ► This review focuses on advances achieved in such pathway engineering fields for the last two years.

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Publisher
Database: Elsevier - ScienceDirect
Journal: Current Opinion in Biotechnology - Volume 22, Issue 5, October 2011, Pages 627–633
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us