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More than a feeling: discovering, understanding, and influencing mechanosensing pathways

Paper ID Volume ID Publish Year Pages File Format Full-Text
15959 42479 2011 7 PDF Available
Title
More than a feeling: discovering, understanding, and influencing mechanosensing pathways
Abstract

The ability of cells to extract biophysical information from their extracellular environment and convert it to biochemical signals is known as mechanotransduction. Here we detail three passive, ‘inside-out’ mechanotransduction mechanisms with an emphasis on the mechanosensing pathways involved in creating these signal: Rho/ROCK, stretch-activated channels, and ‘Molecular Strain Gauges.’ We also examine how molecular tools have been used to perturb these pathways to better understand their interconnectivity. However, perturbing pathways may have unintended confounding effects, which must also be addressed. By discovering and understanding mechanosensitive pathways, the ability to influence them for clinical applications increases.

► ‘Inside-out’ mechanotransduction is examined with an emphasis on mechanosensing pathways. ► The three paradigms of ‘inside-out’ mechanotransduction pathways are Rho/ROCK, Stretch-Activated Channels, and ‘Molecular Strain Gauges’. ► The design of systems to perturb these pathways allows for a better understanding of their interconnectivity. ► Perturbing pathways may have unintended confounding effects.

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More than a feeling: discovering, understanding, and influencing mechanosensing pathways
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Publisher
Database: Elsevier - ScienceDirect
Journal: Current Opinion in Biotechnology - Volume 22, Issue 5, October 2011, Pages 648–654
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us