fulltext.study @t Gmail

Infection and tissue engineering in segmental bone defects — a mini review

Paper ID Volume ID Publish Year Pages File Format Full-Text
15969 42479 2011 5 PDF Available
Title
Infection and tissue engineering in segmental bone defects — a mini review
Abstract

As tissue engineering becomes more of a clinical reality through the ongoing bench to bedside transition, research in this field must focus on addressing relevant clinical situations. Although most in vivo work in the area of bone tissue engineering focuses on bone regeneration within sterile, surgically created defects, there is a growing need for the investigation of bone tissue engineering approaches within contaminated or scarred wound beds, such as those that may be encountered following traumatic injury or during delayed reconstruction/regeneration. Significant work has been performed in the area of local drug delivery via biomaterial carriers, but there is little intersection in the available literature between antibiotic delivery and tissue regeneration. In this review, we examine recent advances in segmental bone defect animal models, bone tissue engineering, and drug delivery with the goal of identifying promising approaches and areas needing further investigation towards developing both a better understanding of and new tissue engineering approaches for addressing infection control while simultaneously initiating bone regeneration.

Research highlights► We review osteomyelitis and implants for local antibiotic delivery to address it. ► We highlight a need for a system to eliminate bacteria and regenerate bone. ► Challenges associated with the creation of an infected animal model are discussed. ► Highlights of current research for bone regeneration in infected sites are presented. ►

First Page Preview
Infection and tissue engineering in segmental bone defects — a mini review
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us
Publisher
Database: Elsevier - ScienceDirect
Journal: Current Opinion in Biotechnology - Volume 22, Issue 5, October 2011, Pages 721–725
Authors
, , , ,
Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us