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Beyond silencing — engineering applications of RNA interference and antisense technology for altering cellular phenotype

Paper ID Volume ID Publish Year Pages File Format Full-Text
15988 42480 2008 6 PDF Available
Title
Beyond silencing — engineering applications of RNA interference and antisense technology for altering cellular phenotype
Abstract

Since its discovery 10 years ago, RNA interference (RNAi) has evolved from a research tool into a powerful method for altering the phenotype of cells and whole organisms. Its near universal applicability coupled with its pinpoint accuracy for suppressing target proteins has altered the landscape of many fields. While there is considerable intellectual investment in therapeutics, its potential extends far beyond. In this review, we explore some of these emerging applications — metabolic engineering for enhancing recombinant protein production in both insect and mammalian cell systems, antisense technologies in bacteria as next generation antibiotics, and RNAi in plant biotechnology for improving productivity and nutritional value.

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Beyond silencing — engineering applications of RNA interference and antisense technology for altering cellular phenotype
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Publisher
Database: Elsevier - ScienceDirect
Journal: Current Opinion in Biotechnology - Volume 19, Issue 5, October 2008, Pages 500–505
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us