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The potential for probiotic manipulation of the gastrointestinal microbiome

Paper ID Volume ID Publish Year Pages File Format Full-Text
16031 42482 2012 10 PDF Available
Title
The potential for probiotic manipulation of the gastrointestinal microbiome
Abstract

Multiple internal and external sites of the healthy human body are colonized by a diversity of symbiotic microbes. The microbial assemblages found in the intestine represent some of the most dense and diverse of these human-associated ecosystems. Unsurprisingly, the enteric microbiome, that is the totality of microbes, their combined genomes, and their interactions with the human body, has a profound impact on physiological aspects of mammalian function, not least, host immune response. Lack of early-life exposure to certain microbes, or shifts in the composition of the gastrointestinal microbiome have been linked to the development and progression of several intestinal and extra-intestinal diseases, including childhood asthma development and inflammatory bowel disease. Modulating microbial exposure through probiotic supplementation represents a long-held strategy towards ameliorating disease via intestinal microbial community restructuring. This field has experienced somewhat of a resurgence over the past few years, primarily due to the exponential increase in human microbiome studies and a growing appreciation of our dependence on resident microbiota to modulate human health. This review aims to review recent regulatory aspects related to probiotics in food. It also summarizes what is known to date with respect to human gastrointestinal microbiota – the niche which has been most extensively studied in the human system – and the evidence for probiotic supplementation as a viable therapeutic strategy for modulating this consortium.

► Studies of the human gut microbiota has increased interest in probiotic therapies. ► Standardization in probiotic trials is essential to address current conflicting data. ► Probiotic regulation differs greatly between countries and continents. ► Consumers and manufacturers will benefit from globally harmonized regulations.

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The potential for probiotic manipulation of the gastrointestinal microbiome
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Publisher
Database: Elsevier - ScienceDirect
Journal: Current Opinion in Biotechnology - Volume 23, Issue 2, April 2012, Pages 192–201
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us