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Cell-free biology: exploiting the interface between synthetic biology and synthetic chemistry

Paper ID Volume ID Publish Year Pages File Format Full-Text
16096 42485 2012 7 PDF Available
Title
Cell-free biology: exploiting the interface between synthetic biology and synthetic chemistry
Abstract

Just as synthetic organic chemistry once revolutionized the ability of chemists to build molecules (including those that did not exist in nature) following a basic set of design rules, cell-free synthetic biology is beginning to provide an improved toolbox and faster process for not only harnessing but also expanding the chemistry of life. At the interface between chemistry and biology, research in cell-free synthetic systems is proceeding in two different directions: using synthetic biology for synthetic chemistry and using synthetic chemistry to reprogram or mimic biology. In the coming years, the impact of advances inspired by these approaches will make possible the synthesis of nonbiological polymers having new backbone compositions, new chemical properties, new structures, and new functions.

Graphical abstractFigure optionsDownload full-size imageDownload high-quality image (126 K)Download as PowerPoint slideHighlights► We focus this review on the role of cell-free systems in synthetic biology efforts. ► Cell-free biology is first examined along with its advantages. ► We then describe recent applications of exploiting the cell's protein synthesis machinery for synthetic chemistry. ► Finally, we consider how synthetic chemistry is used for cell-free synthetic biology.

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Publisher
Database: Elsevier - ScienceDirect
Journal: Current Opinion in Biotechnology - Volume 23, Issue 5, October 2012, Pages 672–678
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us