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Synthetic RNA switches as a tool for temporal and spatial control over gene expression

Paper ID Volume ID Publish Year Pages File Format Full-Text
16097 42485 2012 10 PDF Available
Title
Synthetic RNA switches as a tool for temporal and spatial control over gene expression
Abstract

The engineering of biological systems offers significant promise for advances in areas including health and medicine, chemical synthesis, energy production, and environmental sustainability. Realizing this potential requires tools that enable design of sophisticated genetic systems. The functional diversity of RNA makes it an attractive and versatile substrate for programming sensing, information processing, computation, and control functions. Recent advances in the design of synthetic RNA switches capable of detecting and responding to molecular and environmental signals enable dynamic modulation of gene expression through diverse mechanisms, including transcription, splicing, stability, RNA interference, and translation. Furthermore, implementation of these switches in genetic circuits highlights the potential for building synthetic cell systems targeted to applications in environmental remediation and next-generation therapeutics and diagnostics.

Graphical abstract.Figure optionsDownload full-size imageDownload high-quality image (262 K)Download as PowerPoint slideHighlights► RNA is a versatile substrate for encoding sensing, processing, and control functions. ► RNA switches detect molecular and environmental signals to modulate gene expression. ► RNA switches interface with endogenous gene networks to regulate cellular functions. ► Applications include environmental remediation and advanced medical interventions.

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Synthetic RNA switches as a tool for temporal and spatial control over gene expression
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Publisher
Database: Elsevier - ScienceDirect
Journal: Current Opinion in Biotechnology - Volume 23, Issue 5, October 2012, Pages 679–688
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us