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Expanding the synthetic biology toolbox: engineering orthogonal regulators of gene expression

Paper ID Volume ID Publish Year Pages File Format Full-Text
16098 42485 2012 6 PDF Available
Title
Expanding the synthetic biology toolbox: engineering orthogonal regulators of gene expression
Abstract

Despite substantial progress in synthetic biology, we still lack the ability to engineer anything as complex as Nature has. One of the many reasons is that we lack the requisite tools for independently controlling the expression of multiple genes in parallel. While our toolbox is still spare, the situation is rapidly changing. This opinion discusses some recent approaches and open challenges in designing orthogonal regulators of gene expression in bacteria.

Graphical abstractFigure optionsDownload full-size imageDownload high-quality image (68 K)Download as PowerPoint slideHighlights► Our ability to engineering orthogonal transcription factors in bacteria is limited. ► RNA-based regulators are particularly promising. ► Engineered two-component systems offer a new powerful tool.

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Expanding the synthetic biology toolbox: engineering orthogonal regulators of gene expression
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Publisher
Database: Elsevier - ScienceDirect
Journal: Current Opinion in Biotechnology - Volume 23, Issue 5, October 2012, Pages 689–694
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us