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Heterologous production of polyketides by modular type I polyketide synthases in Escherichia coli

Paper ID Volume ID Publish Year Pages File Format Full-Text
16103 42485 2012 9 PDF Available
Title
Heterologous production of polyketides by modular type I polyketide synthases in Escherichia coli
Abstract

Heterologous production of polyketide compounds, an important class of natural products with complex chemical structures, was first demonstrated with Streptomyces parvulus in 1984. Although Streptomyces strains are good first options for heterologous polyketide biosynthesis, their slow growth kinetics prompt other hosts to also be considered. Escherichia coli provides key elements of an ideal host in terms of the growth rate, culture conditions, and available recombinant DNA tools. Here we review the current status and potential for metabolic engineering of polyketides in E. coli.

Graphical abstractFigure optionsDownload full-size imageDownload high-quality image (150 K)Download as PowerPoint slideHighlights► E. coli provides key elements of an ideal host for polyketide production. ► Modular type I PKSs offer engineering opportunities in a programmed manner. ► Modular type I PKSs, a platform of synthetic biology.

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Heterologous production of polyketides by modular type I polyketide synthases in Escherichia coli
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Publisher
Database: Elsevier - ScienceDirect
Journal: Current Opinion in Biotechnology - Volume 23, Issue 5, October 2012, Pages 727–735
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us