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Synthetic biological approaches to natural product biosynthesis

Paper ID Volume ID Publish Year Pages File Format Full-Text
16104 42485 2012 8 PDF Available
Title
Synthetic biological approaches to natural product biosynthesis
Abstract

Small molecules produced in Nature possess exquisite chemical diversity and continue to be an inspiration for the development of new therapeutic agents. In their host organisms, natural products are assembled and modified using dedicated biosynthetic pathways. By rationally reprogramming and manipulating these pathways, unnatural metabolites containing enhanced structural features that were otherwise inaccessible can be obtained. Additionally, new chemical entities can be synthesized by developing the enzymes that carry out these complicated chemical reactions into biocatalysts. In this review, we will discuss a variety of combinatorial biosynthetic strategies, their technical challenges, and highlight some recent (since 2007) examples of rationally designed metabolites, as well as platforms that have been established for the production and modification of clinically important pharmaceutical compounds.

Graphical abstractFigure optionsDownload full-size imageDownload high-quality image (148 K)Download as PowerPoint slideHighlights► Reprogramming natural product assembly lines have yielded new compounds. ► Substrate specificity of tailoring enzymes can be exploited to afford derivatives. ► Expression and manipulation of pathways have been performed in surrogate hosts.

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Publisher
Database: Elsevier - ScienceDirect
Journal: Current Opinion in Biotechnology - Volume 23, Issue 5, October 2012, Pages 736–743
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us