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Minimal systems to study membrane–cytoskeleton interactions

Paper ID Volume ID Publish Year Pages File Format Full-Text
16107 42485 2012 8 PDF Available
Title
Minimal systems to study membrane–cytoskeleton interactions
Abstract

In the context of minimal systems design, there are two areas in which the reductionist approach has been particularly successful: studies of molecular motors on cytoskeletal filaments, and of protein–lipid interactions in model membranes. However, a minimal cortex, that is, the interface between membrane and cytoskeleton, has just begun to be functionally reconstituted. A key property of living cells is their ability to change their shape in response to extracellular and intracellular stimuli. Although studied in live cells since decades, the mutual dependence between cytoskeleton and membrane dynamics in these large-scale transformations is still poorly understood. Here we report on inspiring recent in vitro work in this direction, and the promises it holds for a better understanding of key cellular processes.

Graphical abstractFigure optionsDownload full-size imageDownload high-quality image (278 K)Download as PowerPoint slideHighlights► We discuss recent advances in studying membrane–cytoskeleton interactions. ► Membrane deformation and actin structure formation through reconstituted actin networks on lipid bilayers. ► Building minimal cells — methods of actin encapsulation in liposomes. ► Reconstitution of biomimetic actin cortices.

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Publisher
Database: Elsevier - ScienceDirect
Journal: Current Opinion in Biotechnology - Volume 23, Issue 5, October 2012, Pages 758–765
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us