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Analyzing and engineering cell signaling modules with synthetic biology

Paper ID Volume ID Publish Year Pages File Format Full-Text
16111 42485 2012 6 PDF Available
Title
Analyzing and engineering cell signaling modules with synthetic biology
Abstract

Signaling pathways lie at the heart of cellular responses to environmental cues. The ability to reconstruct specific signaling modules ex vivo allows us to study their inherent properties in an isolated environment, which in turn enables us to elucidate fundamental design principles for such motifs. This synthetic biology approach for analyzing natural, well-defined signaling modules will help to bridge the gap between studies on isolated biochemical reactions — which can provide great mechanistic detail but do not capture the complexity of endogenous signaling pathways — and those on entire networks of protein interactions — which offer a systems-level view of signal transduction but obscure the mechanisms that underlie signal transmission and processing. Additionally, minimal signaling modules can be tractably engineered to predictably alter cellular responses, opening up possibilities for creating biotechnologically and biomedically useful cellular devices.

Graphical abstractFigure optionsDownload full-size imageDownload high-quality image (162 K)Download as PowerPoint slideHighlights► Synthetic cascades are used to analyze existing pathways and engineer novel control. ► Signaling modules are studied on scales spanning in vitro to intercellular. ► Study of defined modules yields mechanistic insight and facilitates engineering.

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Publisher
Database: Elsevier - ScienceDirect
Journal: Current Opinion in Biotechnology - Volume 23, Issue 5, October 2012, Pages 785–790
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
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Price was $35.95
You save - $31
Price after discount Only $4.95
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