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Towards synthetic microbial consortia for bioprocessing

Paper ID Volume ID Publish Year Pages File Format Full-Text
16113 42485 2012 5 PDF Available
Title
Towards synthetic microbial consortia for bioprocessing
Abstract

The use of microbial consortia for bioprocessing has been limited by our ability to reliably control community composition and function simultaneously. Recent advances in synthetic biology have enabled population-level coordination and control of ecosystem stability and dynamics. Further, new experimental and computational tools for screening and predicting community behavior have also been developed. The integration of synthetic biology with metabolic engineering at the community level is vital to our ability to apply system-level approaches to building and optimizing synthetic consortia for bioprocessing applications. This review details new methods, tools and opportunities that together have the potential to enable a new paradigm of bioprocessing using synthetic microbial consortia.

Graphical abstractFigure optionsDownload full-size imageDownload high-quality image (133 K)Download as PowerPoint slideHighlights► Communities of microbes exhibit increased production rates and metabolic efficiency. ► Synthetic microbial consortia can perform complex functions by distributing tasks. ► Cell–cell communication and synthetic biology can program ecosystem behavior. ► Metabolic models can predict community behavior and synergy between organisms.

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Publisher
Database: Elsevier - ScienceDirect
Journal: Current Opinion in Biotechnology - Volume 23, Issue 5, October 2012, Pages 798–802
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us