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Tissue engineering 2.0: guiding self-organization during pluripotent stem cell differentiation

Paper ID Volume ID Publish Year Pages File Format Full-Text
16115 42485 2012 10 PDF Available
Title
Tissue engineering 2.0: guiding self-organization during pluripotent stem cell differentiation
Abstract

Human pluripotent stem cell (hPSC) differentiation aims to mimic development using growth factors or small molecules in a time-dependent and dose-dependent manner. However, the cell types produced using this approach are predominantly fetal-like in phenotype and function, limiting their use in regenerative medicine. This is particularly true in current efforts to produce pancreatic beta cells, wherein robust pancreatic progenitor maturation can only be accomplished upon transplantation into mice. Recent studies have suggested that hPSC-derived cells are capable of self-organizing in vitro, revealing a new paradigm for creating mature cells and tissues. Tissue engineering strategies that provide subtle and dynamic signals to developmentally naïve cells may be applied to mimic in vitro the self-organization aspects of pancreatic development.

Graphical abstractFigure optionsDownload full-size imageDownload high-quality image (305 K)Download as PowerPoint slideHighlights► Self-organization is a property of developmental systems and pluripotent stem cells. ► Tissue engineering approaches can be applied to control self-organization in vitro. ► Maturation of pluripotent stem cells in vitro may be promoted by self-organization. ► Subtle, dynamic signals are provided to pluripotent cells through self-organization.

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Tissue engineering 2.0: guiding self-organization during pluripotent stem cell differentiation
Publisher
Database: Elsevier - ScienceDirect
Journal: Current Opinion in Biotechnology - Volume 23, Issue 5, October 2012, Pages 810–819
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering