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Material strategies for creating artificial cell-instructive niches

Paper ID Volume ID Publish Year Pages File Format Full-Text
16116 42485 2012 6 PDF Available
Title
Material strategies for creating artificial cell-instructive niches
Abstract

There has been a tremendous growth in the use of biomaterials serving as cellular scaffolds for tissue engineering applications. Recently, advanced material strategies have been developed to incorporate structural, mechanical, and biochemical signals that can interact with the cell and the in vivo environment in a biologically specific manner. In this article, strategies such as the use of composite materials and material processing methods to better mimic the extracellular matrix, integration of mechanical and topographical properties of materials in scaffold design, and incorporation of biochemical cues such as cytokines in tethered, soluble, or time-released forms are presented. Finally, replication of the dynamic forces and biochemical gradients of the in vivo cellular environment through the use of microfluidics is highlighted.

Graphical abstractFigure optionsDownload full-size imageDownload high-quality image (107 K)Download as PowerPoint slideHighlights► Biomaterial selection based on origin, biodegradability, and microstructure. ► Bulk and surface biochemical modification of scaffolds for presentation of cytokines. ► Designing scaffolds with in vivo-like mechanical properties and topography. ► Use of microfluidics to replicate dynamic mechanical and biochemical parameters.

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Publisher
Database: Elsevier - ScienceDirect
Journal: Current Opinion in Biotechnology - Volume 23, Issue 5, October 2012, Pages 820–825
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us