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Progress in computational protein design

Paper ID Volume ID Publish Year Pages File Format Full-Text
16145 42487 2007 7 PDF Available
Title
Progress in computational protein design
Abstract

Current progress in computational structure-based protein design is reviewed in the areas of methodology and applications. Foundational advances include new potential functions, more efficient ways of computing energetics, flexible treatments of solvent, and useful energy function approximations, as well as ensemble-based approaches to scoring designs for inclusion of entropic effects, improvements to guaranteed and to stochastic search techniques, and methods to design combinatorial libraries for screening and selection. Applications include new approaches and successes in the design of specificity for protein folding, binding, and catalysis, in the redesign of proteins for enhanced binding affinity, and in the application of design technology to study and alter enzyme catalysis. Computational protein design continues to mature and advance.

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Progress in computational protein design
Publisher
Database: Elsevier - ScienceDirect
Journal: Current Opinion in Biotechnology - Volume 18, Issue 4, August 2007, Pages 305–311
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering