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Spatial complexity and control of a bacterial cell cycle

Paper ID Volume ID Publish Year Pages File Format Full-Text
16150 42487 2007 8 PDF Available
Title
Spatial complexity and control of a bacterial cell cycle
Abstract

A major breakthrough in understanding the bacterial cell cycle is the discovery that bacteria exhibit a high degree of intracellular organization. Chromosomal loci and many protein complexes are positioned at particular subcellular sites. In this review, we examine recently discovered control mechanisms that make use of dynamically localized protein complexes to orchestrate the Caulobacter crescentus cell cycle. Protein localization, notably of signal transduction proteins, chromosome partition proteins, and proteases, serves to coordinate cell division with chromosome replication and cell differentiation. The developmental fate of daughter cells is decided before completion of cytokinesis, via the early establishment of cell polarity by the distribution of activated signaling proteins, bacterial cytoskeleton, and landmark proteins.

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Spatial complexity and control of a bacterial cell cycle
Publisher
Database: Elsevier - ScienceDirect
Journal: Current Opinion in Biotechnology - Volume 18, Issue 4, August 2007, Pages 333–340
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering