fulltext.study @t Gmail

From large-scale assays to mechanistic insights: computational analysis of interactions

Paper ID Volume ID Publish Year Pages File Format Full-Text
16173 42488 2011 7 PDF Available
Title
From large-scale assays to mechanistic insights: computational analysis of interactions
Abstract

The activity in the living cell is carried out by a myriad network of interactions between macromolecules. These include interactions between proteins that form a functional complex, a protein modifying another protein in a transient interaction, a transcription factor that binds a specific DNA locus triggering a change in chromatin or transcription, and so on. Characterization of these interactions in terms of timing, context, and function is crucial for understanding how cells carry out basic biological processes. The recent years have led to the introduction of many assays for probing these interactions in a systematic and large-scale manner. However, there is a large gap between assay results and understanding of biological systems. The challenge for computational methods is to bridge this gap by combining results of different assays and introducing statistical methodologies. In this review we discuss recent advances in approaches dealing with these challenges, and key directions for the future.

First Page Preview
From large-scale assays to mechanistic insights: computational analysis of interactions
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us
Publisher
Database: Elsevier - ScienceDirect
Journal: Current Opinion in Biotechnology - Volume 22, Issue 1, February 2011, Pages 87–93
Authors
, ,
Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us