fulltext.study @t Gmail

Quantitative phosphoproteomic analysis of signaling network dynamics

Paper ID Volume ID Publish Year Pages File Format Full-Text
16215 42491 2008 6 PDF Available
Title
Quantitative phosphoproteomic analysis of signaling network dynamics
Abstract

Protein phosphorylation mediated cellular signaling is a highly regulated, dynamic process that controls many aspects of cellular biology. Over the past few years many methods have been developed to quantify temporal dynamics of protein phosphorylation, including mass spectrometry, which can be applied in both an unbiased, discovery mode and in a targeted mode to monitor specific phosphorylation sites. Other methods, such as kinase activity assays and antibody microarrays, have been applied to quantify central nodes in the signaling network, yielding intriguing biological insights. This review provides a concise overview of the latest advances in the quantitative analysis of signaling dynamics including a brief commentary on the future of the field.

First Page Preview
Quantitative phosphoproteomic analysis of signaling network dynamics
Publisher
Database: Elsevier - ScienceDirect
Journal: Current Opinion in Biotechnology - Volume 19, Issue 4, August 2008, Pages 404–409
Authors
,
Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering