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From stem cells and cadaveric matrix to engineered organs

Paper ID Volume ID Publish Year Pages File Format Full-Text
16231 42492 2009 8 PDF Available
Title
From stem cells and cadaveric matrix to engineered organs
Abstract

The definitive treatment for end-stage heart failure, organ transplant, is limited by the supply of donor organs. Successful allograft recipients suffer significant adverse effects from chronic antirejection medications. Positive clinical treatment of injured myocardium with stem/progenitor cells has led to hope that one day autologous stem-cell-derived whole or partial donor organs can be generated. Advances in the ability to isolate (or generate) stem or progenitor cells that can give rise to beating cardiocyte-like cells and vascular components, and the advent of human iPS cell technology when combined with recent advances in the generation of perfusable complex tissue scaffolds has moved the field closer to creation of a transplantable heart. As cardiac tissue engineering matures, several other simpler cardiac tissues, such as patches for focal use and human cell test beds for drug screening and drug discovery, are emerging.

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From stem cells and cadaveric matrix to engineered organs
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Publisher
Database: Elsevier - ScienceDirect
Journal: Current Opinion in Biotechnology - Volume 20, Issue 5, October 2009, Pages 598–605
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us