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Life in cellulose houses: symbiotic bacterial biosynthesis of ascidian drugs and drug leads

Paper ID Volume ID Publish Year Pages File Format Full-Text
16250 42493 2010 7 PDF Available
Title
Life in cellulose houses: symbiotic bacterial biosynthesis of ascidian drugs and drug leads
Abstract

Ascidians (tunicates; sea squirts) are sources of diverse, bioactive natural products, one of which is an approved drug and many of which are potent drug leads. It has been shown that symbiotic bacteria living with ascidians produce some of the bioactive compounds isolated from whole animals, and indirect evidence strongly implicates symbiotic bacteria in the synthesis of many others. However, for the majority the producing organism has not been identified. In cases where a symbiotic origin has been definitively assigned, the resulting data lead to improved paths to drug discovery and development from marine animals. This review traces evidence for symbiotic production where such evidence exists and describes the strengths and limitations of that evidence.

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Life in cellulose houses: symbiotic bacterial biosynthesis of ascidian drugs and drug leads
Publisher
Database: Elsevier - ScienceDirect
Journal: Current Opinion in Biotechnology - Volume 21, Issue 6, December 2010, Pages 827–833
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering