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Essential genes on metabolic maps

Paper ID Volume ID Publish Year Pages File Format Full-Text
16257 42495 2006 9 PDF Available
Title
Essential genes on metabolic maps
Abstract

Within the past five years genome-scale gene essentiality data sets have been published for ten diverse bacterial species. These data are a rich source of information about cellular networks that we are only beginning to explore. The analysis of these data, very heterogeneous in nature, is a challenging task. Even the definition of ‘essential genes’ in various genome-scale studies varies from genes ‘absolutely required for survival’ to those ‘strongly contributing to fitness’ and robust competitive growth. A comparative analysis of gene essentiality across multiple organisms based on projection of experimentally observed essential genes to functional roles in a collection of metabolic pathways and subsystems is emerging as a powerful tool of systems biology.

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Essential genes on metabolic maps
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Publisher
Database: Elsevier - ScienceDirect
Journal: Current Opinion in Biotechnology - Volume 17, Issue 5, October 2006, Pages 448–456
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us