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Microstructured extracellular matrices in tissue engineering and development

Paper ID Volume ID Publish Year Pages File Format Full-Text
16267 42495 2006 6 PDF Available
Title
Microstructured extracellular matrices in tissue engineering and development
Abstract

Microscale heterogeneity in the extracellular matrix (ECM) provides spatial information that allows tissues to develop and function properly in vivo. This heterogeneity in composition (chemistry) and structure (geometry) creates distinct microenvironments for the cells that comprise a tissue. In response, populations of cells can coordinate their behaviors across micrometer-to-millimeter length scales to function as a unified whole. We believe techniques to mimic the microscale heterogeneity of the ECM in vitro will revolutionize studies that examine how large groups of cells interact. Micropatterned ECMs used for engineering perfused microvascular networks and functional epidermis and for understanding symmetry-breaking events in epithelial morphogenesis illustrate potential applications in tissue engineering and development.

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Microstructured extracellular matrices in tissue engineering and development
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Publisher
Database: Elsevier - ScienceDirect
Journal: Current Opinion in Biotechnology - Volume 17, Issue 5, October 2006, Pages 518–523
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
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