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Shaping up nucleic acid computation

Paper ID Volume ID Publish Year Pages File Format Full-Text
16290 42497 2010 9 PDF Available
Title
Shaping up nucleic acid computation
Abstract

Nucleic acid-based nanotechnology has always been perceived as novel, but has begun to move from theoretical demonstrations to practical applications. In particular, the large address spaces available to nucleic acids can be exploited to encode algorithms and/or act as circuits and thereby process molecular information. In this review we not only revisit several milestones in the field of nucleic acid-based computation, but also highlight how the prospects for nucleic acid computation go beyond just a large address space. Functional nucleic acid elements (aptamers, ribozymes, and deoxyribozymes) can serve as inputs and outputs to the environment, and can act as logical elements. Into the future, the chemical dynamics of nucleic acids may prove as useful as hybridization for computation.

First Page Preview
Shaping up nucleic acid computation
Publisher
Database: Elsevier - ScienceDirect
Journal: Current Opinion in Biotechnology - Volume 21, Issue 4, August 2010, Pages 392–400
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering