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Systems biology of the gut: the interplay of food, microbiota and host at the mucosal interface

Paper ID Volume ID Publish Year Pages File Format Full-Text
16303 42497 2010 12 PDF Available
Title
Systems biology of the gut: the interplay of food, microbiota and host at the mucosal interface
Abstract

Our intestinal tract is colonized since birth by complex and subject-specific microbial communities that interact with the host. The human adult microbiota has recently been characterized by deep metagenomic sequencing and several hundreds of intestinal genomes have been characterized at the sequence level. Moreover, the transcriptional response of the host and selected microbes has been identified both in animal model systems and in human. Similarly, the transcriptional response of the host to different diets has been determined in humans, germ-free and gene knockout animals. These developments bring the intestinal tract in the realm of systems biology. An integrated, modular modelling framework that cross-links top-down and bottom-up approaches for the various levels of biological organization is paramount for the understanding of intestinal function.

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Publisher
Database: Elsevier - ScienceDirect
Journal: Current Opinion in Biotechnology - Volume 21, Issue 4, August 2010, Pages 539–550
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us