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Systems biology of apoptosis signaling networks

Paper ID Volume ID Publish Year Pages File Format Full-Text
16304 42497 2010 5 PDF Available
Title
Systems biology of apoptosis signaling networks
Abstract

Apoptosis is a complex but highly defined cellular program of cell demolition. Apoptosis can be triggered by the extrinsic or the intrinsic death pathways. Deregulation of apoptosis leads to a number of serious diseases, including cancer. A substantial progress in understanding apoptotic signaling networks has been recently achieved using systems biology. This review will give an overview of the contemporary models of apoptotic signaling networks. The potential of the dynamic models, which include all known components of the network, versus the importance of searching for new components of the networks using different screening techniques will be discussed. The further development of apoptotic signaling networks should provide ways to sensitize cells toward apoptosis and provide new therapies for cancer treatment.

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Publisher
Database: Elsevier - ScienceDirect
Journal: Current Opinion in Biotechnology - Volume 21, Issue 4, August 2010, Pages 551–555
Authors
,
Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us