fulltext.study @t Gmail

Challenges in synthetically designing mammalian circadian clocks

Paper ID Volume ID Publish Year Pages File Format Full-Text
16305 42497 2010 10 PDF Available
Title
Challenges in synthetically designing mammalian circadian clocks
Abstract

Synthetic biology, in which complex, dynamic biological systems are designed or reconstructed from basic biological components, can help elucidate the design principles of such systems. However, this engineering approach has only been applied to a few simple biological systems. The circadian clock is appropriate for this approach, since it is a dynamic system with complex transcriptional and post-transcriptional circuits that have been comprehensively described. Rational synthesis of the properties of the suprachiasmatic nucleus, the central clock tissue of the circadian system that controls many dynamic behaviors, will be important for understanding the neural-circuit systems that control physiological behaviors. These approaches will provide a deeper understanding of the biological clock, and of clinical problems associated with it, such as sleep disorders.

First Page Preview
Challenges in synthetically designing mammalian circadian clocks
Publisher
Database: Elsevier - ScienceDirect
Journal: Current Opinion in Biotechnology - Volume 21, Issue 4, August 2010, Pages 556–565
Authors
, , ,
Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering