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Perfusion electrodeposition of calcium phosphate on additive manufactured titanium scaffolds for bone engineering

Paper ID Volume ID Publish Year Pages File Format Full-Text
1635 87 2011 10 PDF Available
Title
Perfusion electrodeposition of calcium phosphate on additive manufactured titanium scaffolds for bone engineering
Abstract

A perfusion electrodeposition (P-ELD) system was reported to functionalize additive manufactured Ti6Al4 V scaffolds with a calcium phosphate (CaP) coating in a controlled and reproducible manner. The effects and interactions of four main process parameters – current density (I), deposition time (t), flow rate (f) and process temperature (T) – on the properties of the CaP coating were investigated. The results showed a direct relation between the parameters and the deposited CaP mass, with a significant effect for t (P = 0.001) and t–f interaction (P = 0.019). Computational fluid dynamic analysis showed a relatively low electrolyte velocity within the struts and a high velocity in the open areas within the P-ELD chamber, which were not influenced by a change in f. This is beneficial for promoting a controlled CaP deposition and hydrogen gas removal. Optimization studies showed that a minimum t of 6 h was needed to obtain complete coating of the scaffold regardless of I, and the thickness was increased by increasing I and t. Energy-dispersive X-ray and X-ray diffraction analysis confirmed the deposition of highly crystalline synthetic carbonated hydroxyapatite under all conditions (Ca/P ratio = 1.41). High cell viability and cell–material interactions were demonstrated by in vitro culture of human periosteum derived cells on coated scaffolds. This study showed that P-ELD provides a technological tool to functionalize complex scaffold structures with a biocompatible CaP layer that has controlled and reproducible physicochemical properties suitable for bone engineering.

Keywords
Electrodeposition; Perfusion; Calcium phosphate; Titanium scaffold; Bone engineering
First Page Preview
Perfusion electrodeposition of calcium phosphate on additive manufactured titanium scaffolds for bone engineering
Publisher
Database: Elsevier - ScienceDirect
Journal: Acta Biomaterialia - Volume 7, Issue 5, May 2011, Pages 2310–2319
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering