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Where chemistry meets biology: the chemoenzymatic synthesis of nonribosomal peptides and polyketides

Paper ID Volume ID Publish Year Pages File Format Full-Text
16437 42501 2007 8 PDF Available
Title
Where chemistry meets biology: the chemoenzymatic synthesis of nonribosomal peptides and polyketides
Abstract

Intensive studies on modular biosynthetic assembly line machinery have provided researchers with a profound knowledge of how nonribosomal peptides and polyketides used in different therapeutic areas are produced in nature. This has opened the door for projects aiming to manipulate the assembly of these small molecules by directed and combinatorial approaches to produce novel compounds both in vivo and in vitro. Here, we highlight a set of recent chemoenzymatic attempts towards the synthesis of nonribosomal peptides and polyketides that aim to generate these structurally demanding compounds through the combined utilization of synthetic chemical tools and recombinant natural product metabolic enzymes.

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Where chemistry meets biology: the chemoenzymatic synthesis of nonribosomal peptides and polyketides
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Publisher
Database: Elsevier - ScienceDirect
Journal: Current Opinion in Biotechnology - Volume 18, Issue 6, December 2007, Pages 513–520
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us