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Influenza virus-specific cytotoxic T lymphocytes: a correlate of protection and a basis for vaccine development

Paper ID Volume ID Publish Year Pages File Format Full-Text
16440 42501 2007 8 PDF Available
Title
Influenza virus-specific cytotoxic T lymphocytes: a correlate of protection and a basis for vaccine development
Abstract

Since influenza A viruses of the H5N1 subtype continue to circulate in wild and domestic birds and cause an ever increasing number of human cases, it is feared that H5N1 viruses may cause the next influenza pandemic. Therefore, there is considerable interest in the development of vaccines that confer protection against infections with these viruses or ideally, protection against influenza viruses of different subtypes. For the development of broad-protective vaccines the induction of virus-specific cytotoxic T lymphocytes (CTL) may be an important target, since it has been demonstrated that CTL contribute to protective immunity and are largely directed to epitopes shared by influenza viruses of various subtypes. In the present paper, the possibility to develop (cross-reactive) CTL-inducing vaccines is discussed.

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Influenza virus-specific cytotoxic T lymphocytes: a correlate of protection and a basis for vaccine development
Publisher
Database: Elsevier - ScienceDirect
Journal: Current Opinion in Biotechnology - Volume 18, Issue 6, December 2007, Pages 529–536
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering