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In pursuit of a super producer—alternative paths to high producing recombinant mammalian cells

Paper ID Volume ID Publish Year Pages File Format Full-Text
16443 42501 2007 8 PDF Available
Title
In pursuit of a super producer—alternative paths to high producing recombinant mammalian cells
Abstract

Recombinant mammalian cells are used to produce numerous, high-value protein therapeutics. Generating hyper-producing cell lines is crucial for delivery of products to ailing patients. Better understanding of the complex trait of hyperproductivity can facilitate the creation of hyper-producing cell lines. Ruminating over the reported transcriptomic and proteomic studies, we attempt to assess whether high productivity response is a result of minute changes occurring globally or large alterations observed locally at the molecular level. We present here our philosophical perspective on the alternative routes to high productivity. We contend that given the advances in genome-scale technologies and data analysis approaches, insights gained from elucidating the gene–trait relationship underlying hyperproductivity will accelerate the development of hyperproductive processes.

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In pursuit of a super producer—alternative paths to high producing recombinant mammalian cells
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Publisher
Database: Elsevier - ScienceDirect
Journal: Current Opinion in Biotechnology - Volume 18, Issue 6, December 2007, Pages 557–564
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us