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Origin and analysis of microbial population heterogeneity in bioprocesses

Paper ID Volume ID Publish Year Pages File Format Full-Text
16460 42503 2010 14 PDF Available
Title
Origin and analysis of microbial population heterogeneity in bioprocesses
Abstract

Heterogeneity of industrial production cultures is accepted to a certain degree; however, the underlying mechanisms are seldom perceived or included in the development of new bioprocess control strategies. Population heterogeneity and its basics, perceptible in the diverse proficiency of cells, begins with asymmetric birth and is found to recess during the life cycle. Since inefficient subpopulations have significant impact on the productivity of industrial cultures, cellular heterogeneity needs to be detected and quantified by using high speed detection tools like flow cytometry. Possible origins of population heterogeneity, sophisticated fluorescent techniques for detection of individual cell states, and cutting-edge Omics-technologies for extended information beyond the resolution of fluorescent labelling are highlighted.

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Origin and analysis of microbial population heterogeneity in bioprocesses
Publisher
Database: Elsevier - ScienceDirect
Journal: Current Opinion in Biotechnology - Volume 21, Issue 1, February 2010, Pages 100–113
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering