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Backbone flexibility in computational protein design

Paper ID Volume ID Publish Year Pages File Format Full-Text
16491 42505 2009 9 PDF Available
Title
Backbone flexibility in computational protein design
Abstract

The field of computational protein design has produced striking successes, including the engineering of novel enzymes. Many of these achievements employed methodologies that sample amino acid side-chains on a fixed backbone, while methods that explicitly model backbone flexibility have so far largely focused on the design of new structures rather than functions. Recent methodological improvements in conformational sampling techniques, some borrowed from the field of robotics to model mechanically accessible conformations, now provide exciting opportunities to explore amino acid sequences and backbone structures simultaneously. Incorporating functional constraints into flexible backbone design should help to achieve challenging engineering goals that exploit the role of conformational variability in controlling biological processes, while more generally advancing biophysical understanding of the relationship between variations in protein sequence, structure, dynamics, and function.

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Backbone flexibility in computational protein design
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Publisher
Database: Elsevier - ScienceDirect
Journal: Current Opinion in Biotechnology - Volume 20, Issue 4, August 2009, Pages 420–428
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
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Full-text PDF Download
Online Support
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