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Porous bioactive diopside (CaMgSi2O6) ceramic microspheres for drug delivery

Paper ID Volume ID Publish Year Pages File Format Full-Text
1652 88 2010 10 PDF Available
Title
Porous bioactive diopside (CaMgSi2O6) ceramic microspheres for drug delivery
Abstract

Ideal bioceramic microspheres for bone regeneration need to be bioactive and degradable, but at the same time possess a controlled drug-release ability. The main disadvantage of the currently available microspheres is their failure to combine these properties. The aim of this study is to develop bioactive ceramic microspheres with optimal properties for use in bone-tissue regeneration. In this study, we utilize diopside (CaMgSi2O6, DP) with proven excellent bioactivity and degradation ability to develop microspheres by controlling their porosity and size, and further modify their surface with polymer to enhance and control their drug-loading/release ability. The phase composition, surface and inner microstructure, and porosity of DP microspheres were tested. Results indicate that carbon powders as porogens with various contents determined the porosity of the porous DP microspheres. The drug-loading and release ability of dexamethazone (DEX) from porous DP microspheres was regulated by their porosity and size. Poly(lactide-co-glycolide) modification forms a film on the surface of DP microspheres and resulted in an enhanced DEX-loading and release ability of the microspheres. Results presented here indicate that the developed DP microspheres have the potential to be used as bioactive filling materials for bone-tissue regeneration.

Keywords
DP microspheres; Porosity; PLGA modification; Drug release
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Porous bioactive diopside (CaMgSi2O6) ceramic microspheres for drug delivery
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Publisher
Database: Elsevier - ScienceDirect
Journal: Acta Biomaterialia - Volume 6, Issue 3, March 2010, Pages 820–829
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us