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Fragment-based lead discovery: a chemical update

Paper ID Volume ID Publish Year Pages File Format Full-Text
16538 42507 2006 10 PDF Available
Title
Fragment-based lead discovery: a chemical update
Abstract

Fragment-based lead discovery constructs drug leads from small molecular fragments. In theory, this is a highly efficient method for drug discovery, and the technique has become enormously popular in the past few years. In this review, I describe how a variety of approaches in fragment-based lead discovery — including NMR, X-ray crystallography, mass spectrometry, functional screening, and in silico screening — have produced drug leads. Although the examples show that the technique can reliably generate potent molecules, there is still much work to be done to maintain the efficiency of molecules’ binding affinities as fragments are linked, expanded, and otherwise improved.

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Publisher
Database: Elsevier - ScienceDirect
Journal: Current Opinion in Biotechnology - Volume 17, Issue 6, December 2006, Pages 643–652
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
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